Common Licorice root is a well-known herb primarily used as a harmonizer in Chinese herbal formulas. It has been employed as medicine in China for at least 2,000 years. Modern science has shown Licorice to have value as an anti-inflammatory1,2,3,4 and anti-microbial5,6,7 agent. It has also been shown to reduce itching8 in atopic dermatitis.
Schrofelbauer, B. et al., Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signaling. Biochem J. 2009. 421(3):473-82.
Azimov, MM. et al., Pharmacological study of the anti-inflammatory agent glyderinine. Farmakol Toksikol. 1988. 51(4):90-3.
Kim KR, et al. Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice. J Biomed Biotechnol. 2010;2010:709378.
Matsui S, et al. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int Immunopharmacol. 2004 Dec 15;4(13):1633-44.
Krausser, R. et al., In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites. J Antimicrob Chemother. 2004, 54(1):243-6..
Li, J. et al., Comparative analysis of the effect of glycyrrhizin diammonium and lithium chloride on infectious bronchitis virus infection in vitro. Avian Pathol. 2009, 38(3):215-21.
Hatano T, Kusuda M, Inada K et al. 2005. Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Phytochemistry 66: 2047–2055.
8. Saeedi, M. et al., The treatment of atopic dermatitis with licorice gel. J Dermatolog Treat. 2003. 14(3):153-7.
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